Welcome to AggMod, a repository of mathematical models of macroscopic mechanisms of protein aggregation. For more information, please see the About page. Implemented models are available through the Models page. If you have any comments or suggestions, please visit our Contact page.
Protein aggregation causes problems in both the biomedical sciences and biotechnology. Misfolded proteins and the formation of toxic aggregates are implicated in a wide variety of diseases, such as the relatively well-known neurological diseases Alzheimer's, Parkinson's and Huntington's, as well as many others.
There are numerous proteins that are known to aggregate. Click on the image for more details on these proteins.
A wide variety of reaction mechanisms have been proposed to characterize protein aggregation. Click on the image to search for published mechanisms within this repository.
The Schnell lab is located in the Brehm Center for Diabetes Research (Brehm Center researchers are pictured here).
University of Michigan